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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression <t>of</t> <t>p21</t> and <t>PUMA</t> induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.
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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression <t>of</t> <t>p21</t> and <t>PUMA</t> induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.
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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression <t>of</t> <t>p21</t> and <t>PUMA</t> induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.
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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression <t>of</t> <t>p21</t> and <t>PUMA</t> induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.
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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression <t>of</t> <t>p21</t> and <t>PUMA</t> induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.
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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression <t>of</t> <t>p21</t> and <t>PUMA</t> induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.
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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression <t>of</t> <t>p21</t> and <t>PUMA</t> induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.
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TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression of p21 and PUMA induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.

Journal: Translational Cancer Research

Article Title: TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H

doi: 10.21037/tcr-24-2130

Figure Lengend Snippet: TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression of p21 and PUMA induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.

Article Snippet: The primary antibody against TC2N (Cat. #: HPA027549) was obtained from Sigma-Aldrich; c-Met (Cat. #: 25869-1-AP), phospho-c-Met (Cat. #: 30737-1-AP), p21 (Cat. #: 10355-1-AP), PUMA (Cat. #: 55120-1-AP), p53 (Cat. #: 10442-1-AP) and Actin (Cat. #: 66009-1-Ig) were purchased from Proteintech Group (Wuhan, China); secondary antibodies (Cat. #: A0216 and A0208) were obtained from Beyotime.

Techniques: Expressing, Phospho-proteomics, Over Expression, Negative Control